Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6123 | 6123-30821 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | D67E, N348I | K103N | K20R, V60I, S68G, V118I, D121Y, K122E, I135T, T200I, R211K, A272P, I293V, Q343H, M357T, T369V, S379C | E29A, G273R |
| >6123-30821| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEAKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPRIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYHEPFKILKTGKYARTRGA HTNDVKQLVEAVQKIATECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L24I | L10I, T12N, I62V, L63P, V77I |
| >6123-30821| codons 1-99 PQITLWQRPIVNIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |