Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6122 | 6122-30821 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82T, I84V | L24I, L33F, L89LV | L10V, I13IV, I15V, R41K, K55KR, L63P, I66IF, A71LV, I72T, I93IL |
| >6122-30821| codons 1-99 PQITLWQRPVVTVKVGGQLKEALIDTGADDTIFEEMNLPGKWKPKIIGGIGGFIRVRQYD QIPIEFCGHKVTGTVLVGPTPTNVIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219HN | Y188L | V35T, T39A, V60I, V118I, K122E, I135T, E203EK, H208Y, R211K, K223KE, A272P, E297K, D324E, I329L, G333E, A355AG, V365I, E399ED |
| >6122-30821| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIKELRQYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAELQKQEQGQWTYQIYQEPFKNLKTGKYGRMRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |