<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6122 6122-30821 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, V82T, I84V L24I, L33F, L89LV L10V, I13IV, I15V, R41K, K55KR, L63P, I66IF, A71LV, I72T, I93IL  
>6122-30821| codons 1-99
PQITLWQRPVVTVKVGGQLKEALIDTGADDTIFEEMNLPGKWKPKIIGGIGGFIRVRQYD
QIPIEFCGHKVTGTVLVGPTPTNVIGRNVLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219HN Y188L   V35T, T39A, V60I, V118I, K122E, I135T, E203EK, H208Y, R211K, K223KE, A272P, E297K, D324E, I329L, G333E, A355AG, V365I, E399ED  
>6122-30821| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLLVGSDLEIGQHRTKIKELRQYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQEQGQWTYQIYQEPFKNLKTGKYGRMRGA
HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006