<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6120 6120-30924 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74V, L210W, T215Y K219E, N348I K103N, Y181C V108I T27S, T39TA, S68G, K122E, D123N, I135L, G196E, E203EK, L228H, V245E, A272P, K277R, E297A, M357T, G359S, K366R, I380L, V381I, T386TI, E399G  
>6120-30924| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKNGTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DENFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIKELRQHLWRWGFYTPDEKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRSA
HTNDVRQLTEAVQKIATESLIIWGKIPKFKLPIQKETWGA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L10F, L33F I13V, K14R, N37D, R41K, I62V, I64V, A71T, T91A  
>6120-30924| codons 1-99
PQITLWQRPFVTVRIGGQLKEALLDTGADDTVFEEMDLPGKWKPKIIGGIGGFVKVRQYD
QVLVEICGHKTIGTVVVGPTPANIIGRNLLAQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006