Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6119 | 6119-30924 | Italy | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10V, T12P, G17D, K20R, E35D, M36I, R57K, Q61N, L63S, I72T, L89M |
| >6119-30924| codons 1-99 PQITLWQRPVVPIKIGDQLREALIDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVKQYD NISIEICGHKATGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215F | V35T, K49R, D123E, I135T, S162C, E169A, K173AT, Q174K, D177E, I178L, Q207E, R211K, V245Q, E248D, A272P, V276T, K277R, T286A, E291D, V292I, I293V, E297AST, F346C, R356K, G359S, T377Q, S379C, K390R, Q394L, E399D |
| >6119-30924| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILAPFRTKNPELVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPCKNLKTGKYAKMRSA HTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPILKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |