Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6118 | 6118-30923 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L23I, L33F, K43KT, N88D | L10I, I13V, E34Q, M36MI, I62V, L63P, A71V, I72M, C95F |
| >6118-30923| codons 1-99 PQITLWQRPIVTVKIGGQLKEAILDTGADDTVFQEINLPGRWTPKIIGGVGGFVKVRQYD QVPIEICGHKVMGTVLVGPTPANIIGRDLMTQIGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219D, N348I | L100I | K20R, V35VI, T39AS, E44D, V60I, S68G, K102Q, V118I, K122KE, D123E, I135IT, S162Y, V179VI, T200TA, E203EK, Q207E, H208HY, R211K, D218E, D237N, A272P, K277R, R284K, T286A, A288S, V292I, E297K, G335S, R358K, G359S, K390KR |
| >6118-30923| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICSELEKDGKISKIGPENPYNTPI FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKQKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPEDKHQKEPPFLWMGYELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKSLTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKILKTGKYARMKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |