<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6118 6118-30923 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L23I, L33F, K43KT, N88D L10I, I13V, E34Q, M36MI, I62V, L63P, A71V, I72M, C95F  
>6118-30923| codons 1-99
PQITLWQRPIVTVKIGGQLKEAILDTGADDTVFQEINLPGRWTPKIIGGVGGFVKVRQYD
QVPIEICGHKVMGTVLVGPTPANIIGRDLMTQIGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67G, K219D, N348I L100I   K20R, V35VI, T39AS, E44D, V60I, S68G, K102Q, V118I, K122KE, D123E, I135IT, S162Y, V179VI, T200TA, E203EK, Q207E, H208HY, R211K, D218E, D237N, A272P, K277R, R284K, T286A, A288S, V292I, E297K, G335S, R358K, G359S, K390KR  
>6118-30923| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICSELEKDGKISKIGPENPYNTPI
FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKQKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII
YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPEDKHQKEPPFLWMGYELHPNKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKSLTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKILKTGKYARMKSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006