<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6116 6116-30610 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184I, L210W, T215Y V75M, K219R K101E, Y181C, G190A V108I, F227L E6K, V21I, V35I, T39A, E40F, K43E, R83K, K102Q, V118I, K122E, S162Y, Q174R, G196E, E203K, Q207E, H208Y, R211K, H221Y, K223E, L228R, A272P, L283I, E297R, D324E, Q334E, P345Q, F346Y, R356K, M357R, G359S, A360T, S379C, K390R, E399D  
>6116-30610| codons 1-399
PISPIKTVPVKLKPGMDGPKIKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV
FAIKKKDSDKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLEQKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKRNPDIVI
CQYIDDLYVASDLEIEQHRTKIKELREYLWKWGFYTPDRKYQEEPPLRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEQYKNLKTGKYAKRRST
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73T I13M, K14R, K20I, A22V, E35D, M36I, L63P, I64V, I85V, C95V  
>6116-30610| codons 1-99
PQITLWQRPFVTMRIGGQLIEVLLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD
QIPVEICGHKAITTVLVGPTPVNVVGRNLMTQIGVTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006