Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6116 | 6116-30610 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I13M, K14R, K20I, A22V, E35D, M36I, L63P, I64V, I85V, C95V |
| >6116-30610| codons 1-99 PQITLWQRPFVTMRIGGQLIEVLLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKAITTVLVGPTPVNVVGRNLMTQIGVTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184I, L210W, T215Y | K219R | K101E, Y181C, G190A | V108I, F227L | E6K, V21I, V35I, T39A, E40F, K43E, R83K, K102Q, V118I, K122E, S162Y, Q174R, G196E, E203K, Q207E, H208Y, R211K, H221Y, K223E, L228R, A272P, L283I, E297R, D324E, Q334E, P345Q, F346Y, R356K, M357R, G359S, A360T, S379C, K390R, E399D |
| >6116-30610| codons 1-399 PISPIKTVPVKLKPGMDGPKIKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLEQKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKRNPDIVI CQYIDDLYVASDLEIEQHRTKIKELREYLWKWGFYTPDRKYQEEPPLRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEQYKNLKTGKYAKRRST HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |