Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6108 | 6108-30930 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | G190A | V35T, T39A, V60I, V118I, K122E, D123DN, I135T, Q174QR, D177E, I178IM, Q197K, T200A, E203D, H208Y, R211K, H221Y, A272P, T286A, I293V, E297R, G333E, Q334Y, M357R, A360T, T386I, K390R, E399D |
| >6108-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEMVI YQYVDDLYVASDLEIGKHRAKIDELRQYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKNLKTGKYARRRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82A | L23I, F53L, Q58E | L10I, I15V, K20R, E21K, E35D, M36I, N37D, K55R, R57K, I62V, L63V, G68E, H69K, A71V, I93M |
| >6108-30930| codons 1-99 PQITLWQRPIVTIKVGGQLRKAILDTGADDTVLEDIDLPGRWKPKLIAGIGGLVRVKEYD QVVIEICEKKVIGTVLVGPTPANIIGRNLLTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |