<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6104 6104-30604 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L10F, L24I, L33F, G73C T12E, I13V, L19I, K20R, K55R, R57K, L63P, A71V, V77I, T91S  
>6104-30604| codons 1-99
PQITLWQRPFVEVKIGGQIREALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFVRVKQYD
QIPIEICGHKVICTVLIGPTPANIIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M K101E, Y188L, G190A   V35T, T39TK, K43E, V60I, V106I, V118I, K122E, D123E, I135V, T139A, K166R, V179I, T200AE, E203K, R211K, K223E, A272P, L283I, E297K, K311R, P313PKQT, D324DE, I329IV, K350R, A355AG, R356K, K366R, A371AV, K390KR  
>6104-30604| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL
DEEFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIII
YQYVDDLLVASDLEIGQHREKIKELRQHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTKEAE
LELAENREILRETVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLRTGKYGKMRGA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006