Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6104 | 6104-30604 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, L33F, G73C | T12E, I13V, L19I, K20R, K55R, R57K, L63P, A71V, V77I, T91S |
| >6104-30604| codons 1-99 PQITLWQRPFVEVKIGGQIREALIDTGADDTVFEEMNLPGRWKPKIIGGIGGFVRVKQYD QIPIEICGHKVICTVLIGPTPANIIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K101E, Y188L, G190A | V35T, T39TK, K43E, V60I, V106I, V118I, K122E, D123E, I135V, T139A, K166R, V179I, T200AE, E203K, R211K, K223E, A272P, L283I, E297K, K311R, P313PKQT, D324DE, I329IV, K350R, A355AG, R356K, K366R, A371AV, K390KR |
| >6104-30604| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIII YQYVDDLLVASDLEIGQHREKIKELRQHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTKEAE LELAENREILRETVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLRTGKYGKMRGA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |