Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6099 | 6099-30618 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L33I, Q58E, G73S | L10I, K20V, E35D, M36I, N37D, Q61D, I62V, L63P, I66F, C67Y, A71T, I72R |
| >6099-30618| codons 1-99 PQITLWQRPIVTIKIGGQLVEALLDTGADDTVIEDIDLPGRWKPKLIGGIGGFLKVREYD DVPIEFYGHKTRSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K103N | V108I, Y318F | K20R, V35M, K43N, S68G, D123E, I135T, S162SN, D177E, R211K, V245E, A272P, K281R, I293V, E297K, Q334N, M357T, G359S, K366R, T369V, E370D, A371V, I375IV, A376S, T377I |
| >6099-30618| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELENEGKISKIGPENPYNTPV FAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVRQLVDVVQKVSIESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |