Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6098 | 6098-30611 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LIV, V75M, M184I, L210W | T215D, K219R | L100LI, K101PT, K103N | Y318F | V35I, K43Q, E44D, V90I, V118I, K122E, I135T, I178IM, E194EQ, G196E, R211K, D218E, V245IM, A272P, A288S, I293V, E297KR, K311R, M357T, I375V, T386I |
| >6098-30611| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPVF AIKKKNSTKWRKVMDFRELNKRTQDFWEIQLGIPHPAGITKNKSVTVLDVGDAYFSIPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIY QYIDDLYVGSDLQIEQHRTKIEELRQHLWKWGFDTPERKHQKEPPFLWMGYELHPDKWTV QPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTREAEL ELAENREILREPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGAH TNDVKQLTEAVQKVATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, V82A, L90M | Q58E, L89V | L10I, I13V, E34Q, M36L, N37D, I62V, L63P, A71I |
| >6098-30611| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTILQELDLPGRWKPKMVGGIGGFMKVREYD QVPIEICGHKIIGTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |