<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6098 6098-30611 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74LIV, M184I, L210W V75M, T215D, K219R L100LI, K101PT, K103N Y318F V35I, K43Q, E44D, V90I, V118I, K122E, I135T, I178IM, E194EQ, G196E, R211K, D218E, V245IM, A272P, A288S, I293V, E297KR, K311R, M357T, I375V, T386I  
>6098-30611| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPVF
AIKKKNSTKWRKVMDFRELNKRTQDFWEIQLGIPHPAGITKNKSVTVLDVGDAYFSIPLD
EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVIY
QYIDDLYVGSDLQIEQHRTKIEELRQHLWKWGFDTPERKHQKEPPFLWMGYELHPDKWTV
QPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTREAEL
ELAENREILREPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGAH
TNDVKQLTEAVQKVATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54M, V82A, L90M Q58E, L89V L10I, I13V, E34Q, M36L, N37D, I62V, L63P, A71I  
>6098-30611| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTILQELDLPGRWKPKMVGGIGGFMKVREYD
QVPIEICGHKIIGTVLVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006