Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6096 | 6096-30904 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L10F, L33F, Q58E | K20KQ, E34Q, D60E, Q61E, L63P, I64IV, V77I |
| >6096-30904| codons 1-99 PQITLWQRPFVTIKIGGQLQEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVREYE EIPVEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | V35R, T39A, V60VI, S68G, K82KR, V118I, K122E, D123E, I135T, D177N, G196E, T200A, A272P, V292I, I293V, E297R, I326L, G335GS, G359S, A371V, T377L, T386I, A400T |
| >6096-30904| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPI FAIKKKDGTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTREAE LELAENREILKEPVHGVYYDPSKDLLAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIALESIVIWGKIPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |