<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6096 6096-30904 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A L10F, L33F, Q58E K20KQ, E34Q, D60E, Q61E, L63P, I64IV, V77I  
>6096-30904| codons 1-99
PQITLWQRPFVTIKIGGQLQEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVREYE
EIPVEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y       V35R, T39A, V60VI, S68G, K82KR, V118I, K122E, D123E, I135T, D177N, G196E, T200A, A272P, V292I, I293V, E297R, I326L, G335GS, G359S, A371V, T377L, T386I  
>6096-30904| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPI
FAIKKKDGTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI
YQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTREAE
LELAENREILKEPVHGVYYDPSKDLLAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIALESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006