Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6092 | 6092-30717 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, L33F, G73S | E35ED, M36ML, R41K, K55R, R57K, I62V, L63P, A71V, I72L |
| >6092-30717| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFEDLNLPGKWKPKIIGGIGGFVRVKQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K101E, Y181C, G190S | K43E, V60I, A98S, V111VI, V118VI, K122E, D123E, I135IT, G196E, T200A, I202IV, E203ED, H221CY, V245E, A272P, K277R, K281R, I293V, E297K, R358K, V365VI, A376T, T377Q, K390R |
| >6092-30717| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDIGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIEQHRAKVDELRQHLWRWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDIKQLTEAVQKITQESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |