Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6088 | 6088-30603 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F, I84V, L90M | L23I, L33F, G48E, Q58E | L10I, I13V, E34K, N37T, I62V, L63P, V77I, L89M |
| >6088-30603| codons 1-99 PQITLWQRPIVTVKIGGQLKEAILDTGADDTVFKEMTLPGRWKPKIIEGIGGFVKVREYD QVPIEICGHKAIGTVVIGPTPFNVIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, D67N, Q151M | A62V, V75I, F116Y, T215V, K219E | G190A | K238T | P4T, T39A, S68K, R83K, V90I, K101Q, K122E, R172K, T200A, V245K, V276T, K281R, E297K, D324E, Q334K, M357T, A371V, A376T, T377L, K390R, A400S |
| >6088-30603| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FVIKRKNKTKWRKLIDFRELNKKTQDFWEIQLGIPHPAGLQKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFKKQNPDIVI YQYMDDLYVASDLEIGQHRAKIEELRQHLLRWGFVTPDEKHQKEPPFLWMGYELHPDTWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKTKQLCRLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGKGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKITLESIVIWGKTPKFRLPIQKETWES |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |