Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6087 | 6087-30528 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V179D | K11R, E44D, R83RK, V118I, K122E, D123E, I178IM, E203K, Q207E, H208Y, R211K, K223T, E224D, A272P, T286TA, V292VI, I293V, E297T, E312EQ, R356K, M357MK, G359GS, A371V, I375V, K390R, E399D |
| >6087-30528| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMDI YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQTDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTTEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F, G73S | L10I, K55R, L63P, A71V, I72IM, V77I, T91TS |
| >6087-30528| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIGGIGGFVRVRQYD QIPIEICGHKVMSTVLIGPTPANIIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |