Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6086 | 6086-30528 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, V82F, L90M | G73GS, L89V | L10I, I13V, L19V, K20I, M36I, D60E, Q61N, I62V, L63Q, I64M, A71V |
| >6086-30528| codons 1-99 PQITLWQRPIVTVKIGGQVIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYE NVQMEICGHKVISTVVVGPTPFNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | V75A, K219Q | E40D, V60I, K64H, T69N, V118I, D123E, S162D, G196E, D218E, L228H, K238R, Q242H, A272P, R284K, T286A, I293V, P294A, E297R, L303M, Q334E, A360T, V365I, Q367L, K395R, E399D |
| >6086-30528| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTDLEKEGKISKIGPENPYNTPI FAIHKKNSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDRWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVALTREAE LEMAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT HTNDIKLLTEAVQKIATESIVIWGKTPKFKLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |