<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6086 6086-30528 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L76V, V82F, L90M G73GS, L89V L10I, I13V, L19V, K20I, M36I, D60E, Q61N, I62V, L63Q, I64M, A71V  
>6086-30528| codons 1-99
PQITLWQRPIVTVKIGGQVIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYE
NVQMEICGHKVISTVVVGPTPFNIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F V75A, K219Q     E40D, V60I, K64H, T69N, V118I, D123E, S162D, G196E, D218E, L228H, K238R, Q242H, A272P, R284K, T286A, I293V, P294A, E297R, L303M, Q334E, A360T, V365I, Q367L, K395R, E399D  
>6086-30528| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTDLEKEGKISKIGPENPYNTPI
FAIHKKNSNRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDRWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVALTREAE
LEMAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDIKLLTEAVQKIATESIVIWGKTPKFKLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006