Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6085 | 6085-30526 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82C, L90M | F53L, G73S | L10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95L |
| >6085-30526| codons 1-99 PQITLWQRPIVTVKVGGQLTEALLDTGADDTVLQEIDLPGRWKPKMIMGIGGLVKVRQYD EVPIEICGHKVISTVLVGPTPCNIIGRNLMTQIGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74LI, L210W, T215Y | D67G, K219Q | K103N | S68G, V90VI, V106I, V118I, K122E, D123DN, I135T, Q197E, T200A, E203D, Q207E, D218E, Q242QH, V245K, A272P, I293V, I329IV, Q334S, M357S, A360V, A376T, T377M, I382IL, T386A |
| >6085-30526| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSITVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGEHRAKIDELREHLWRWGFYTPEQKHQKEPPFLWMGYELHPDKWT VHPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGSGQWTYQIYQEPFKNLKTGKYARSRGV HTNDVKQLTEAVQKITMESIVLWGKAPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |