Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6084 | 6084-30526 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47IV, I54V, V82A, L90M | L33F, F53FL, G73ST | L10I, L19IV, E34Q, R41RK, D60DE, I62V, L63P, C67CF, A71V, I72LV, V77I |
| >6084-30526| codons 1-99 PQITLWQRPIVTIKIGGQVKEALLDTGADDTVFQEMNLPGKWKPKMVGGIGGLVKVRQYE QVPIEIFGHKVVTTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | K103KN, Y181YC, G190GA | K101KHNQ, V108VI | V90VI, K122E, D123DE, I135IM, S162Y, D177E, V179VI, D192DN, T200A, E203D, Q207QE, R211RK, H221HY, D237DE, A272P, K281KR, I293V, E297KR, R358K, A371V, A376S, K395KR, E396ED, E399D | P236PH |
| >6084-30526| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVF AIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKNKSVTILDVGDAYFSVPLD EEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIIIC QYMDDLYVASNLEIGQHRAKIDELREHLLKWGFFTPDQKYQKEPPFLWMGYELHHEKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGAH TNDVKQLTEVVQKISTESIVIWGKTPKFKLPIQRDTWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |