<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6084 6084-30526 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47IV, I54V, V82A, L90M L33F, F53FL, G73ST L10I, L19IV, E34Q, R41RK, D60DE, I62V, L63P, C67CF, A71V, I72LV, V77I  
>6084-30526| codons 1-99
PQITLWQRPIVTIKIGGQVKEALLDTGADDTVFQEMNLPGKWKPKMVGGIGGLVKVRQYE
QVPIEIFGHKVVTTVLIGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, T215F K219Q K103KN, Y181YC, G190GA K101KHNQ, V108VI V90VI, K122E, D123DE, I135IM, S162Y, D177E, V179VI, D192DN, T200A, E203D, Q207QE, R211RK, H221HY, D237DE, A272P, K281KR, I293V, E297KR, R358K, A371V, A376S, K395KR, E396ED, E399D P236PH
>6084-30526| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVF
AIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKNKSVTILDVGDAYFSVPLD
EEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIIIC
QYMDDLYVASNLEIGQHRAKIDELREHLLKWGFFTPDQKYQKEPPFLWMGYELHHEKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGAH
TNDVKQLTEVVQKISTESIVIWGKTPKFKLPIQRDTWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006