<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6083 6083-30521 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82C, I84V, L90M L10F, V11I, K43T, G73T I13V, I15V, K20I, L24M, M36I, L63P, C67Y, H69R, A71V  
>6083-30521| codons 1-99
PQITLWQRPFITVKVGGQLIEALMDTGADDTVLEEINLPGRWTPKIIGGIGGFVKVRQYD
QIPIEIYGRKVITTVLVGPTPCNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219E K103NS   V35I, E40F, K43Q, V118I, D121Y, K122E, S162T, K173KQ, Q174QK, D177N, G196E, H208Y, R211K, D218E, L228H, Q242H, A272P, K277R, I293IV, E297A, V317A, R356RK, E370D, A376S, E399D  
>6083-30521| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFRQKNPNIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTDAVQKISTESIVIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006