Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6083 | 6083-30521 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82C, I84V, L90M | L10F, V11I, K43T, G73T | I13V, I15V, K20I, L24M, M36I, L63P, C67Y, H69R, A71V |
| >6083-30521| codons 1-99 PQITLWQRPFITVKVGGQLIEALMDTGADDTVLEEINLPGRWTPKIIGGIGGFVKVRQYD QIPIEIYGRKVITTVLVGPTPCNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219E | K103NS | V35I, E40F, K43Q, V118I, D121Y, K122E, S162T, K173KQ, Q174QK, D177N, G196E, H208Y, R211K, D218E, L228H, Q242H, A272P, K277R, I293IV, E297A, V317A, R356RK, E370D, A376S, E399D |
| >6083-30521| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTFLEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFRQKNPNIVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTDAVQKISTESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |