Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6081 | 6081-30519 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184V | A62V, V75I, F77L, F116Y, T215V, K219Q | A98G | V35IMT, S68K, V118I, K122E, T139Q, I202V, Q207K, R211Q, F214M, V245M, A272P, I293V, E297K, I329L, V365I, I382T, T386I, K390R, E399D |
| >6081-30519| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVF VIKRKDKTKWRKLIDLRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAFYSIPLD EDFRKYTAFTIPSINNEQPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIY QYVDDLYVGSDLEIGQHRTKVEELRKHLLQWGMVTPDQKHQKEPPFLWMGYELHPDKWTV QPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAEL ELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAH TNDIKQLTEAVQKIATESIVTWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L33F, K43T, F53L, G73S | L10I, I13V, L19I, K20R, E35D, M36I, N37E, K55R, I62V, L63P, A71V, V77I |
| >6081-30519| codons 1-99 PQITLWQRPIVTVKIGGQIREALLDTGADDTIFEDIELPGRWTPKIVGGIGGLVRVRQYD QVPIEICGHKVISTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |