<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6081 6081-30519 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M, M184V A62V, V75I, F77L, F116Y, T215V, K219Q   A98G V35IMT, S68K, V118I, K122E, T139Q, I202V, Q207K, R211Q, V245M, A272P, I293V, E297K, I329L, V365I, I382T, T386I, K390R, E399D F214M
>6081-30519| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPVF
VIKRKDKTKWRKLIDLRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAFYSIPLD
EDFRKYTAFTIPSINNEQPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYVDDLYVGSDLEIGQHRTKVEELRKHLLQWGMVTPDQKHQKEPPFLWMGYELHPDKWTV
QPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAEL
ELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAH
TNDIKQLTEAVQKIATESIVTWGKIPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82A, L90M L33F, K43T, F53L, G73S L10I, I13V, L19I, K20R, E35D, M36I, N37E, K55R, I62V, L63P, A71V, V77I  
>6081-30519| codons 1-99
PQITLWQRPIVTVKIGGQIREALLDTGADDTIFEDIELPGRWTPKIVGGIGGLVRVRQYD
QVPIEICGHKVISTVLIGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006