<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6081 6081-30519 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82A, L90M L33F, K43T, F53L, G73S L10I, I13V, L19I, K20R, E35D, M36I, N37E, K55R, I62V, L63P, A71V, V77I  
>6081-30519| codons 1-99
PQITLWQRPIVTVKIGGQIREALLDTGADDTIFEDIELPGRWTPKIVGGIGGLVRVRQYD
QVPIEICGHKVISTVLIGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M, M184V A62V, V75I, F77L, F116Y, T215V, K219Q   A98G P1L, V35IMT, S68K, V118I, K122E, T139Q, I202V, Q207K, R211Q, V245M, A272P, I293V, E297K, I329L, V365I, I382T, T386I, K390R, E399D, A400T F214M
>6081-30519| codons 1-400
LISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FVIKRKDKTKWRKLIDLRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAFYSIPL
DEDFRKYTAFTIPSINNEQPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKVEELRKHLLQWGMVTPDQKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDIKQLTEAVQKIATESIVTWGKIPKFRLPIQKETWDT

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006