Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6075 | 6075-30717 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | L100I, K103N | V35M, T39E, E44D, V60VI, V118I, K122P, I135T, K166R, D177K, G196E, T200A, E203K, H208Y, R211RK, K223Q, A272P, V276I, K277R, L283I, I293V, P294Q, V317A, I329IV, P345E, R356K, K366R, S379C, V381I, K390R |
| >6075-30717| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICEELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPKIVI YQYMDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIRQLCKLIRGTKALTEVVQLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQEEFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIATECIIIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I50V, I54V, V82A, L90M | L33F, F53FL, L89V | T4S, L10I, I13V, L19I, K20T, E35D, M36I, N37D, I62V, L63H, H69Q, A71V, I72V, T74S, I93L, C95F |
| >6075-30717| codons 1-99 PQISLWQRPIVTVKIGGQITEALLDTGADDTVFEDIDLPGRWKPKMIMGVGGLVKVRQYD QVHIEICGQKVVGSVLVGPTPANIIGRNVMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |