<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6075 6075-30717 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, L210W, T215Y K219R L100I, K103N   V35M, T39E, E44D, V60VI, V118I, K122P, I135T, K166R, D177K, G196E, T200A, E203K, H208Y, R211RK, K223Q, A272P, V276I, K277R, L283I, I293V, P294Q, V317A, I329IV, P345E, R356K, K366R, S379C, V381I, K390R  
>6075-30717| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICEELEKDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPKIVI
YQYMDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIRQLCKLIRGTKALTEVVQLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGQGQWTYQIYQEEFKNLKTGKYAKMRGA
HTNDVRQLTEAVQKIATECIIIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I50V, I54V, V82A, L90M L33F, F53FL, L89V T4S, L10I, I13V, L19I, K20T, E35D, M36I, N37D, I62V, L63H, H69Q, A71V, I72V, T74S, I93L, C95F  
>6075-30717| codons 1-99
PQISLWQRPIVTVKIGGQITEALLDTGADDTVFEDIDLPGRWKPKMIMGVGGLVKVRQYD
QVHIEICGQKVVGSVLVGPTPANIIGRNVMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006