Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6073 | 6073-30709 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, M184MV, L210W, T215Y | K219E | A98G | T27S, V35I, K43E, S68G, K102R, K122E, K173E, T200A, L228H, E297K, F346Y, M357T, S379G, T386I, K390R | E40CF |
| >6073-30709| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARTRGA HTNDVKQLTEAVQKIATEGIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L33F, K43T, G73S | L10V, E34Q, M36L, I62V, L63P, I64L, A71V, I93L |
| >6073-30709| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTIFQELNLPGRWTPKIVGGIGGFLKVRQYD QVPLEICGHKVISTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |