<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6071 6071-30604 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, L210W, T215Y K219R K103N A98G K11KR, K20R, V35I, K43E, E44A, I94L, V111I, V118I, K122E, D123E, I135T, K166R, V189I, G196E, H208Y, R211K, A272P, K281KR, I293V, E297K, I326ILV, K350R, M357MT, G359S, T386I  
>6071-30604| codons 1-399
PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGLPHPGGLKKNKSVTVLDIGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYMDDLYIGSDLEIEQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLRTGKYARTRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, V82F, L90M L23I, L33F L10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89M  
>6071-30604| codons 1-99
PQITLWQRPIVKVRIGGQLKEAILDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVRQYD
QVPIEICGHKAIGAVVIGPTPFNIIGRNMMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006