Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6071 | 6071-30604 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, L210W, T215Y | K219R | K103N | A98G | K11KR, K20R, V35I, K43E, E44A, I94L, V111I, V118I, K122E, D123E, I135T, K166R, V189I, G196E, H208Y, R211K, A272P, K281KR, I293V, E297K, I326ILV, K350R, M357MT, G359S, T386I |
| >6071-30604| codons 1-399 PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGLPHPGGLKKNKSVTVLDIGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYIGSDLEIEQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLRTGKYARTRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82F, L90M | L23I, L33F | L10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89M |
| >6071-30604| codons 1-99 PQITLWQRPIVKVRIGGQLKEAILDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIGAVVIGPTPFNIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |