<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6069 6069-30925 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A L24I L10I, I13IV, N37D, K55KR, D60E, Q61QE, I62V, L63T, I64MV, C67E, A71V, I72T, T74A, V77I, I93L  
>6069-30925| codons 1-99
PQITLWQRPIVTVKIGGQLKEALIDTGADDTVLEEMDLPGRWKPKLIGGIGGFIRVRQYE
EVTVEIEGHKVTGAVLIGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, M184V, L210W, T215Y       K43AT, V118I, Q174E, D192DN, G196K, R211K, L228LH, A272P, K281R, T286A, E297K, P313S, I326V, Q334H, G335S, A360T, T369V, A371V, I375V, E399D  
>6069-30925| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELETEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYVDDLYVGSNLEIKQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE
LELAENREILKESVHGVYYDPSKDLVAEIQKQGHSQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLVEVVQKVATESIVIWGKTPKFKLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006