Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6066 | 6066-30829 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10F, L33I, Q58E | I13V, K20R, M36I, N37T, R41K, I62V, L63T, I64V, T74S |
| >6066-30829| codons 1-99 PQITLWQRPFVTVKIGGQLREALLDTGADDTVIEEITLPGKWKPKLIGGIGGFVKVREYD QVTVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | V75I, F77L, F116Y | K103N | T7P, K49R, S68G, R83K, W88WG, G196K, T200I, A272P, L283I, I293V, E297A, Q334N, V372L, A376T, T386A, A400T |
| >6066-30829| codons 1-400 PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKRKDGTRWRKLIDLRELNKKTQDFGEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIKQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEALQKITTESIVIWGKAPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |