Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6065 | 6065-30805 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35I, W88C, K101Q, D123E, S162C, T200S, R211K, A272P, I293V, E297K, D324E, I329L, I375V, A376AP, T377TI, T386I | P55PA |
| >6065-30805| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENAYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRSKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKVPIESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LF | G16E, E35D, I62V, L63S, H69K, A71T, V77I |
| >6065-30805| codons 1-99 PQITLWQRPFVTIKIEGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QVSIEICGKKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |