Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6064 | 6064-30804 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | A62V, V75T, K219QR | A98G | T39TA, K122E, E138EA, I142T, S162SN, G196E, T200AE, E203K, Q207E, L228LI, A272P, I293V, M357T, G359S, A371V, A376T, T377Q |
| >6064-30804| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FVIKKKNSDKWRKVTDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGTRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHREKIKELREHLWRWGFYTPDRKHQKEPPFIWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKITQESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | K55R, L63P, I64V, I66V, P79A, I93L, C95F |
| >6064-30804| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVRVRQYD QIPVEVCGHKAITTVLVGATPVNVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |