<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6063 6063-30728 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82A L33I, K43T L10I, I13V, K20M, E35D, M36I, R41RK, R57K, I62V, L63LP, I64V, A71AT, T74TA, N83S, T91S  
>6063-30728| codons 1-99
PQITLWQRPIVTVKIGGQLMEALLDTGADDTVIEDINLPGKWTPKMIVGIGGFVKVKQYD
QVPVEICGHKTIGAVLVGPTPASIIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, L210LW, T215F K219Q K103N   S3SC, V35L, T39A, V60I, T69N, K122E, G196E, Q197K, Q207E, R211RK, D218E, L228H, A272AP, K277R, T286P, A288T, I293V, E297A, G335S, A360T, A376C  
>6063-30728| codons 1-399
PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEKHRTKIEELREHLWKWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKTLTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEAVQKICTESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006