Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6062 | 6062-30728 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | Y181C | K101N, V108I | K20R, V21I, K43Q, V60I, V118VI, K122E, I135T, I142IV, Q174QR, D177DE, T200TA, Q207E, R211K, E224ED, L228R, S251Q, A272P, L283I, I293V, E297A, G333E, Q334H, T338S, R356K, G359S, A360T, K366KR, S379C, T386I, K390R, E399ED | E138T |
| >6062-30728| codons 1-399 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNTTPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI CQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKDPPFRWMGYELHPDKWT VQPIVLPEKDQWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWSYQIYQEPFKNLKTGKYAKMRST HTNDVRQLTEAVQKIATECIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, V82T, I84V, L90M | G73ST, L89LV | L10I, V11L, I15V, G16A, L19V, K20I, M36I, L63P, A71V, I72L, I85V |
| >6062-30728| codons 1-99 PQITLWQRPILTIKVAGQVIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGHKVLTTVLVGPTPTNVVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |