<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6062 6062-30728 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47IV, I54V, V82T, I84V, L90M G73ST, L89LV L10I, V11L, I15V, G16A, L19V, K20I, M36I, L63P, A71V, I72L, I85V  
>6062-30728| codons 1-99
PQITLWQRPILTIKVAGQVIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVRQYD
QIPIEICGHKVLTTVLVGPTPTNVVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y   Y181C K101N, V108I K20R, V21I, K43Q, V60I, V118VI, K122E, I135T, I142IV, Q174QR, D177DE, T200TA, Q207E, R211K, E224ED, L228R, S251Q, A272P, L283I, I293V, E297A, G333E, Q334H, T338S, R356K, G359S, A360T, K366KR, S379C, T386I, K390R, E399ED E138T
>6062-30728| codons 1-399
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPI
FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSTNNTTPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEIVI
CQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKDPPFRWMGYELHPDKWT
VQPIVLPEKDQWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWSYQIYQEPFKNLKTGKYAKMRST
HTNDVRQLTEAVQKIATECIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006