Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6061 | 6061-30723 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I50V, I54S, V82A | L10I, E34Q, N37S, F53Y, I62V, L63P, I64V, A71V, I72V, T74S, V77I, I85V, I93L |
| >6061-30723| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMSLPGRWKPKLIVGVGGYSKVRQYD QVPVEICGHKVVGSVLIGPTPANIVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219R | K103N | V108I, Y318F | T39TA, K43Q, E44D, V60I, V118I, K122E, I135T, E203K, Q207E, R211K, K223Q, V245E, A272P, I293IV, E297K, I329V, G335S, G359S, A371V, K390R, E399D |
| >6061-30723| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVFYDPSKDLIAEVQKQGQSQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |