Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6060 | 6060-30717 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215F | K219Q | V106A, G190A | F227FL | K20R, V35I, T39A, V60I, T69TN, R83K, V90I, L109I, V118I, D123E, I135T, E138A, I202V, R211K, D218E, A272P, K281R, T286A, E297K, M357T, S379G, T386I, E399D |
| >6060-30717| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPI FAIKKKNSNKWRKLMDFRELNKKTQDFWEIQLGIPHPAGLKKKKSATVIDVGDAYFSIPL DKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKVEELRQHLWKWGFFTPEQKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATEGIVIWGKIPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, G73S | L10I, T12K, I13V, A22V, E35D, M36I, N37D, R57K, I62V, L63P, C67F, H69K, A71V, T91TS |
| >6060-30717| codons 1-99 PQITLWQRPIIKVKIGGQLKEVLLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVKQYD QVPIEIFGKKVISTVLVGPTPVNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |