Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6058 | 6058-30715 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, D67N, M184MI | T215L, K219Q | K101E, Y188L | K20R, K22R, V60I, T69N, E79D, A98S, K122E, E138A, I202V, Q207A, F214L, H221HY, K223E, A272P, K277R, T286A, V292I, I293V, R356K, K388KR |
| >6058-30715| codons 1-399 PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKRKNSNKWRKLVDFRDLNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLLVGSDLEIGQHRTKVEELRAHLLRWGLLTPDQKYQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKTPRFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, G73S | Q18K, K20I, M36MI, N37D, D60E, I62V, L63P, K70R, A71V, I85V, I93L |
| >6058-30715| codons 1-99 PQITLWQRPFVTIKIGGKLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGFVKVRQYE QVPIEICGHRVISTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |