<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6058 6058-30715 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65KR, D67N, M184MI T215L, K219Q K101E, Y188L   K20R, K22R, V60I, T69N, E79D, A98S, K122E, E138A, I202V, Q207A, F214L, H221HY, K223E, A272P, K277R, T286A, V292I, I293V, R356K, K388KR  
>6058-30715| codons 1-399
PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI
FAIKRKNSNKWRKLVDFRDLNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYIDDLLVGSDLEIGQHRTKVEELRAHLLRWGLLTPDQKYQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKIATESIVIWGKTPRFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, G73S Q18K, K20I, M36MI, N37D, D60E, I62V, L63P, K70R, A71V, I85V, I93L  
>6058-30715| codons 1-99
PQITLWQRPFVTIKIGGKLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGFVKVRQYE
QVPIEICGHRVISTVLVGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006