Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6057 | 6057-30709 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48M, I54A, V82A | F53L | L10I, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, A71V, I93L |
| >6057-30709| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMVMGIGGLAKVRQYE EVPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, M184V, L210W, T215Y | Y181C | A98G | P4PS, K20R, V35I, K43Q, E44D, K102KQR, D123E, I135IT, K166R, T200TA, E203K, Q207D, H208Y, R211K, K223E, E224EK, A272P, T286A, I293V, E297K, V317A, Q334E, Y339W, K350R, M357T, G359GS, I375V, A376T, S379C, V381I, T386A |
| >6057-30709| codons 1-399 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKRKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQEKPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTWQIYQEPFKNLRTGKYARTRSA HTNDVKQLTEAVQKVTTECIIIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |