<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6057 6057-30709 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47V, G48M, I54A, V82A F53L L10I, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, A71V, I93L  
>6057-30709| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMVMGIGGLAKVRQYE
EVPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, M184V, L210W, T215Y   Y181C A98G P4PS, K20R, V35I, K43Q, E44D, K102KQR, D123E, I135IT, K166R, T200TA, E203K, Q207D, H208Y, R211K, K223E, E224EK, A272P, T286A, I293V, E297K, V317A, Q334E, Y339W, K350R, M357T, G359GS, I375V, A376T, S379C, V381I, T386A  
>6057-30709| codons 1-399
PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKRKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQEKPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGEGQWTWQIYQEPFKNLRTGKYARTRSA
HTNDVKQLTEAVQKVTTECIIIWGKAPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006