Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6053 | 6053-30606 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10V, I15V, G16E, K20R, E35D, M36I, P39S, I62V, L63P, I64V, A71V, I72V, T74S, I93L |
| >6053-30606| codons 1-99 PQITLWQRPVVTIKVEGQLREALIDTGADDTVLEDINLSGRWKPKLIGGIGGFVKVRQYD QVPVEICGHKVVGSVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V35M, E36EK, T39A, K43E, V118I, D121Y, K122E, D123E, I135T, I178M, T200A, A288S, V292I, I293V, K311R, S322A, R356K, M357T, T386I |
| >6053-30606| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMKICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL YEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEIVPLTEEAE LELAENREILREPVHGVYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |