Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6052 | 6052-30530 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GV, I54IV, V82VA, L90M | L33LF, K43T, N88D | L10I, I15V, L19I, K20R, E34Q, E35D, M36I, N37D, R57K, Q61QH, I62V, L63P, I66IF, A71V, I72IT, I85IV |
| >6052-30530| codons 1-99 PQITLWQRPIVTIKVGGQIREALLDTGADDTVFQDIDLPGRWTPKMIVGIGGFVKVKQYD HVPIEFCGHKVTGTVLVGPTPANIVGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, L210W, T215Y | D67H, V75S, K219D | K101E, Y181C, G190A | K20KR, V35I, T39A, K43KQ, S68N, T69N, D123E, S162F, E203K, Q207E, R211K, D218E, L228H, D250E, A272P, I293IV, T296S, E297K, V317A, I329L, G333E, K350KR, R356K, M357R, G359S, A360T, T386I, E396D, E399D |
| >6052-30530| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQEGKISKIGPENPYNTPVF AIKKKHNNRWRKISDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPLD KEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQFSMTKILEPFRKQNPDIVIC QYVDDLYVASDLEIGQHRTKIKELREHLWKWGFYTPEDKHQKEPPFHWMGYELHPDKWTV QPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLSKEAEL ELAENREILKEPVHGAYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLRTGKYAKRRSTH TNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKDTWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |