Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6051 | 6051-30529 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | T12A, I13V, K20I, M36I, N37D, I62IV, L63P, A71V, I72L |
| >6051-30529| codons 1-99 PQITLWQRPFVAVKIGGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K20R, V35I, K43N, E44ED, V118I, K122E, D123E, I135V, I142IV, V179VI, I195L, T200TA, A272P, K277R, E297K, V317A, M357T, G359S, A371V, A400T |
| >6051-30529| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLELGQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |