Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6050 | 6050-30529 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | V11I, Q58E, G73S, L89V | L10I, I15V, L19Q, K20I, E35N, M36I, K55R, I62V, L63P, A71V, I72V, I85V |
| >6050-30529| codons 1-99 PQITLWQRPIITIKVGGQQIEALLDTGADDTVLENINLPGRWKPKIIGGVGGFVRVREYD QVPIEICGHKVVSTVLVGPTPANIVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | K43Q, D121H, K122E, I135T, S162Y, V179I, E204Q, Q207E, F214L, D218E, L228H, D250E, K277R, A288S, I293V, P294T, E297K, Q334L, G335S, K350R, R356K, A371V, K390R, E399D |
| >6050-30529| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEQLREHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLRTGKYAKMRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |