Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6048 | 6048-30515 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T215Y | L100I, K103N | K49R, T69TN, K122E, I135V, Q207E, V245K, I293V, E297K, Q334E, A371V, I375V, T377M |
| >6048-30515| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKVAMESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IV, I54V, V82A, L90M | F53L | L10Y, I13V, K20I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, I64V, E65EQ, T74TA, L89M |
| >6048-30515| codons 1-99 PQITLWQRPYVTVKIGGQLIEALLDTGADDTVLEDIDLPGKWKPKVIGGIGGLVRVRQYE EVPVQICGHKAIGAVLVGPTPANIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |