Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6047 | 6047-30515 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82F, L90M | L33I, Q58E, G73S, L89V | L10I, I13V, E35D, M36I, Q61QE, I62V, L63PT, C67Y, A71AT, I72IT |
| >6047-30515| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVIEDINLPGRWKPKLIGGIGGFVKVREYD EVTIEIYGHKTTSTVLVGPTPFNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | E36EK, T39E, E44D, K49R, E53D, V118I, K122E, D123E, T139M, G196E, I202V, R211K, A272P, A288AT, P294T, E297R, M357T, A360V, D364E, A376S, S379C, K390R, T397V |
| >6047-30515| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVKICEELEKDGKISRIGPDNPYNTPVF AIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLD EEFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY QYVDDLYVGSDLEIEQHRTKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTLTEVITLTREAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGVH TNEVKQLTEAVQKISTECIVIWGKTPKFRLPIQKEVWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |