<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6047 6047-30515 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82F, L90M L33I, Q58E, G73S, L89V L10I, I13V, E35D, M36I, Q61QE, I62V, L63PT, C67Y, A71AT, I72IT  
>6047-30515| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVIEDINLPGRWKPKLIGGIGGFVKVREYD
EVTIEIYGHKTTSTVLVGPTPFNIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y       E36EK, T39E, E44D, K49R, E53D, V118I, K122E, D123E, T139M, G196E, I202V, R211K, A272P, A288AT, P294T, E297R, M357T, A360V, D364E, A376S, S379C, K390R, T397V  
>6047-30515| codons 2-399
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVKICEELEKDGKISRIGPDNPYNTPVF
AIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLD
EEFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYVDDLYVGSDLEIEQHRTKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTLTEVITLTREAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGVH
TNEVKQLTEAVQKISTECIVIWGKTPKFRLPIQKEVWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006