Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6045 | 6045-30515 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82C, L90M | G73S | I15V, K20T, E35D, N37T, I62V, L63P, A71V, V77I, C95L |
| >6045-30515| codons 1-99 PQITLWQRPLVTIKVGGQLTEALLDTGADDTILEDMTLPGRWKPKIVGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPCNIIGRNLMTQIGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219E | R83K, D123E, E138A, L228LF, A272P, K277R, T286P, E291D, E297K, I326T, Q334L, F346Y, A360V, A376AT, T377Q |
| >6045-30515| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFFWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKALTDVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGLGQWTYQIYQEPYKNLKTGKYARMRGV HTNDVKQLTEAVQKITQESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |