Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6043 | 6043-30505 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | G73S | L10I, T12N, I15V, G16GA, L19P, K20I, M36I, L63P, A71V, I72L, I85V, I93L |
| >6043-30505| codons 1-99 PQITLWQRPIVNIKVAGQPIEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGHKVLSTVLVGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V106A, Y181YC, G190A | F227FL | K20R, V35I, K43E, A98S, K102Q, V118I, D123E, I135T, G196E, H208Y, R211K, K223Q, E224D, A272P, E297K, G335S, Y342F, M357R, R358K, K366R, A371V, A376ST, T386V, K390R |
| >6043-30505| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQKKSATVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIEQHRTKIEELRQYLWKWGFYTPDKKHQQDPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIFQEPFKNLKTGKYARRKGA HTNDVRQLTEVVQKITTESIVIWGKVPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |