Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6041 | 6041-30430 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | E6K, T39N, E44D, V118I, K122E, D123E, I135T, I142IV, D177E, I178M, T200A, V245K, A272P, K275R, K277R, Q278E, I293V, E297K, K311KE, Q334C, A376C, T377TM, I380IV, T386I, E399D |
| >6041-30430| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRELCKLLRGTKALTEVVPLTKEAE LELAENREILEEPVHGVYYDPSKDLIAEIQKQGCGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKICMESVVIWGKIPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, G73T | K20I, M36I, N37D, L63P, H69R, A71V, I72V, I85V, I93L |
| >6041-30430| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGFVKVRQYD QIPIEICGRKVVTTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |