Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6040 | 6040-30429 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V106A | F227L | L109I, V118VI, K122E, S162A, V179I, G196E, T200I, I202V, H208Y, R211RK, V245E, A272P, E297R, D324DE, R356K, G359S, A360T, A371V |
| >6040-30429| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVIDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIEQHRIKVEELRQYLWKWGFYTPDKKHQKEPPLLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L24I, L33F | L10I, I13V, K20R, M36I, N37D, I62V, L63P, I64V |
| >6040-30429| codons 1-99 PQITLWQRPIVTVKIGGQLREALIDTGADDTVFEEIDLPGRWKPKIIGGIGGFVKVRQYD QVPVEICGHKAIGTVVVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |