Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6038 | 6038-30428 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184I, L210W, T215Y | A62V, K219R | G190A | A98G, F227L | K43Q, E44D, V118I, K122E, T200A, E203K, H208Y, R211K, K223E, L228R, V245M, A288S, I293V, P294T, E297R, E308A, I341V, G359S, T369V, A371V, I375V, T377M, T386I |
| >6038-30428| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQEEPPLRWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVTLTREAE LELAENRAILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQVYQEPFKNLKTGKYARMRSA HTNDVKQLVEVVQKVAMESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48AV, I54V, L76V, V82S | L24I, L33F, F53FL, Q58E | L10I, I13V, G16E, R41RK, K55R, L63C, V77I, L89M |
| >6038-30428| codons 1-99 PQITLWQRPIVTVKIEGQLKEALIDTGADDTVFEEMNLPGKWKPKIIVGIGGLVRVREYD QICIEICGHKAIGTVVIGPTPSNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |