<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6038 6038-30428 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, G48AV, I54V, L76V, V82S L24I, L33F, F53FL, Q58E L10I, I13V, G16E, R41RK, K55R, L63C, V77I, L89M  
>6038-30428| codons 1-99
PQITLWQRPIVTVKIEGQLKEALIDTGADDTVFEEMNLPGKWKPKIIVGIGGLVRVREYD
QICIEICGHKAIGTVVIGPTPSNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184I, L210W, T215Y A62V, K219R G190A A98G, F227L K43Q, E44D, V118I, K122E, T200A, E203K, H208Y, R211K, K223E, L228R, V245M, A288S, I293V, P294T, E297R, E308A, I341V, G359S, T369V, A371V, I375V, T377M, T386I  
>6038-30428| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYIDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQEEPPLRWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVTLTREAE
LELAENRAILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQVYQEPFKNLKTGKYARMRSA
HTNDVKQLVEVVQKVAMESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006