Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6036 | 6036-30428 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33I, N88D | L10V, I13V, G16A, K20R, E35D, M36I, R57K, L63P, A71T |
| >6036-30428| codons 1-99 PQITLWQRPVVTVKIAGQLREALLDTGADDTVIEDINLPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKTIGTVLVGPTPANIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K103N | V35L, T39A, E40F, K43E, K122E, D123E, I135T, H208Y, R211K, L283I, V292I, I293V, E297A, D324E, I329L, G335D, R358K, I375V, S379C, T386V, K390R |
| >6036-30428| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQDQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKVATECIVIWGKVPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |