Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6035 | 6035-30423 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C, G190A | V108I | K20R, V35L, T39A, K43E, K101Q, V118I, K122E, I135T, E203D, R211RK, H221Y, V245Q, E248D, K277R, Q278E, I293V, E297T, M357T, G359GS, A360AV, A371AV, T386I |
| >6035-30423| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIDELRQHLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSV HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, V82T | L10V, T12S, L19T, M36MIV, Q61E, L63P, A71V, I72V |
| >6035-30423| codons 1-99 PQITLWQRPVVSIKIGGQTKEALLDTGADDTILEEVNLPGRWKPKIAGGIGGFIKVRQYD EIPIEICGHKVVGTVLVGPTPTNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |