Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6034 | 6034-30423 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | Y188L | E44D, K101KQ, K102KQ, V118I, K122KE, D123X, V179I, T200TA, E203EK, H208Y, R211K, K223Q, V245K, D250E, S251H, V292I, I293V, S322T, G359S, A371V, K390R | Q269H, R284S |
| >6034-30423| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQQKKSVTVLDVGDAYFSIPL DEXFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYIDDLLVGSDLEIGQHRAKIKELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIKLPEKEHWTVNDIQKLVGKLNWASHIYAGIKVKQLCKLLSGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, K20R, E34Q, E35D, M36I, N37D, R57K, D60DE, Q61QHKN, L63AP, A71I, I72V, I93L |
| >6034-30423| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLQDIDLPGRWKPKMIVGIGGFTKVKQYE NIPIEICGHKIVGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |